The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …

Mucosal immune responses to infection and vaccination in the respiratory tract

RC Mettelman, EK Allen, PG Thomas - Immunity, 2022 - cell.com
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

[HTML][HTML] Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions

AI Abulsoud, HM El-Husseiny, AA El-Husseiny… - Biomedicine & …, 2022 - Elsevier
COVID-19 is a worldwide pandemic caused by SARS-coronavirus-2 (SARS-CoV-2). Less
than a year after the emergence of the Covid-19 pandemic, many vaccines have arrived on …

[HTML][HTML] Clinical severity of SARS-CoV-2 Omicron variant compared with delta among hospitalized COVID-19 patients in Belgium during Autumn and Winter Season …

N Van Goethem, PYJ Chung, M Meurisse… - Viruses, 2022 - mdpi.com
This retrospective multi-center matched cohort study assessed the risk for severe COVID-19
(combination of severity indicators), intensive care unit (ICU) admission, and in-hospital …

[HTML][HTML] The COVID-19 pandemic and Alzheimer's disease: Mutual risks and mechanisms

F Chen, Y Chen, Y Wang, Q Ke… - Translational …, 2022 - translationalneurodegeneration …
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially in elderly …

Detailed stratified GWAS analysis for severe COVID-19 in four European populations

F Degenhardt, D Ellinghaus, S Juzenas… - Human molecular …, 2022 - academic.oup.com
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …

[HTML][HTML] The association of APOE genotype with COVID-19 disease severity

J Safdari Lord, J Soltani Rezaiezadeh… - Scientific reports, 2022 - nature.com
COVID-19 has caused the recent pandemic of respiratory infection, which threatened global
health. The severity of the symptoms varies among affected individuals, from asymptotic or …

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

CE Comar, CJ Otter, J Pfannenstiel… - Proceedings of the …, 2022 - National Acad Sciences
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into humans in 2012,
causing highly lethal respiratory disease. The severity of disease may be, in part, because …

[PDF][PDF] Final results of a randomized, placebo-controlled, two-arm, parallel clinical trial of proxalutamide for hospitalized COVID-19 patients: a multiregional, joint …

FA Cadegiani, RA Zimerman, DN Fonseca, MN Correia… - Cureus, 2021 - cureus.com
Background The role of androgens on COVID-19 is well established. Proxalutamide is a
second-generation, non-steroidal antiandrogen (NSAA) with the highest antiandrogen …

[HTML][HTML] Mortality and readmission rates among hospitalized COVID-19 patients with varying stages of chronic kidney disease: a multicenter retrospective cohort

B Appelman, JJ Oppelaar, L Broeders, WJ Wiersinga… - Scientific Reports, 2022 - nature.com
Chronic kidney disease (CKD) has been recognized as a highly prevalent risk factor for both
the severity of coronavirus disease 2019 (COVID-19) and COVID-19 associated adverse …