Living cardiac tissue slices, a pseudo two-dimensional (2D) preparation, have received less
attention than isolated single cells, cell cultures, or Langendorff-perfused hearts in cardiac …

Ca2+ handling within cardiac myocytes underpins coordinated contractile function within the
beating heart. This protocol enables high spatial and temporal Ca2+ imaging of ex vivo …

There is an urgent need for models that faithfully replicate heart failure with preserved
ejection fraction (HFpEF), now recognized as the most common form of heart failure in the …

Spontaneous Ca 2+ release (SCR) can cause triggered activity and initiate arrhythmias.
Intrinsic transmural heterogeneities in Ca 2+ handling and their propensity to disease …

Cardiac electrophysiology is regulated by the autonomic nervous system, and this has both
pathophysiological, and possibly therapeutic importance. Furthermore, chamber differences …

2019-03-19 Assigned to NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF
THE UNIVERSITY OF ILLINOIS reassignment NORTHWESTERN UNIVERSITY …

Diseases of the cardiac conduction system can be debilitating and deadly. Electronic
pacemakers are incredibly effective in the treatment of sinus and AV node dysfunction, yet …

The epicardium has recently gained interest in the cardiovascular field due to its capacity to
support heart regeneration after ischemic injury. Models to study the epicardium of large …

Heart failure (HF) is a major cause of morbidity and mortality worldwide. The global burden
of HF continues to rise, with prevalence rates estimated at 1–2% and incidence approaching …

A special in vitro model maintained with ultrathin cardiac slices with a preserved
architecture, multi-cellularity, and physiology of the heart tissue was used. In our …