Hydrogen peroxide–production, fate and role in redox signaling of tumor cells
C Lennicke, J Rahn, R Lichtenfels… - Cell communication and …, 2015 - Springer
Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …
The thioredoxin antioxidant system
J Lu, A Holmgren - Free radical biology and medicine, 2014 - Elsevier
The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Inhibition of glutamine utilization synergizes with immune checkpoint inhibitor to promote antitumor immunity
JK Byun, M Park, S Lee, JW Yun, J Lee, JS Kim… - Molecular Cell, 2020 - cell.com
Despite its outstanding clinical success, immune checkpoint blockade remains ineffective in
many patients. Accordingly, combination therapy capable of achieving greater antitumor …
many patients. Accordingly, combination therapy capable of achieving greater antitumor …
[HTML][HTML] Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
M Deponte - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …
challenges encountered by all life forms. In the course of evolution, nature optimized …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
Glutathione homeostasis and functions: potential targets for medical interventions
VI Lushchak - Journal of amino acids, 2012 - Wiley Online Library
Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …
against reactive oxygen and nitrogen species. The primary goal of this paper is to …
Redox signaling mediated by thioredoxin and glutathione systems in the central nervous system
Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling
EM Hanschmann, JR Godoy, C Berndt… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …