Connexins are known for their ability to mediate cell-cell communication via gap junctions
and also form hemichannels that pass ions and molecules over the plasma membrane when …

Mitochondrial quality control (MQC) mechanisms are required to maintain a functional
proteome, which enables mitochondria to perform a myriad of important cellular functions …

Background Mitochondrial dysfunction is one of key factors causing heart failure. We
performed a comprehensive analysis of expression of mitochondrial quality control (MQC) …

Mitochondria are the powerhouses of eukaryotic cells, composed mostly of nuclear-encoded
proteins imported from the cytosol. Thus, problems with the import machinery will disrupt …

Mitochondria are vital organelles regulating essential cellular functions. Human
mitochondrial DNA (mtDNA) consists of 37 genes, 13 of which encode mitochondrial …

Human mitochondrial disorders impact tissues with high energetic demands and can be
associated with cardiac muscle disease (cardiomyopathy) and early mortality. However, the …

Mitochondria are double membrane-bound organelles that play critical functions in cells
including metabolism, energy production, regulation of intrinsic apoptosis, and maintenance …

Introduction The analysis of the role of the mitochondria in oxidative damage and skin aging
has been a significant aspect of dermatological research. Mitochondria generate most …

Heat shock proteins (HSPs) are a family of molecular chaperones that regulate essential
protein refolding and triage decisions to maintain protein homeostasis. Numerous co …

Heat Shock Proteins of the 70-kDa family (HSP70s) do not cause cancer by themselves, but
instead protect cells as they transform into cancer. These molecular chaperones bind …