Inflammasome activation at the crux of severe COVID-19

SM Vora, J Lieberman, H Wu - Nature Reviews Immunology, 2021 - nature.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …

COVID-19 vaccines: The status and perspectives in delivery points of view

JY Chung, MN Thone, YJ Kwon - Advanced drug delivery reviews, 2021 - Elsevier
Due to the high prevalence and long incubation periods often without symptoms, the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …

Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

COVID‐19‐associated mucormycosis: an updated systematic review of literature

R Pal, B Singh, SK Bhadada, M Banerjee… - Mycoses, 2021 - Wiley Online Library
In its wake, the COVID‐19 pandemic has ushered in a surge in the number of cases of
mucormycosis. Most cases are temporally linked to COVID‐19; hence, the entity is described …

[PDF][PDF] A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice

SR Leist, KH Dinnon, A Schäfer, VT Longping, K Okuda… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

S Abu-Rumeileh, A Abdelhak, M Foschi, H Tumani… - Journal of …, 2021 - Springer
Abstract Since coronavirus disease-2019 (COVID-19) outbreak in January 2020, several
pieces of evidence suggested an association between the spectrum of Guillain–Barré …

Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

FS Oladunni, JG Park, PA Pino, O Gonzalez… - Nature …, 2020 - nature.com
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease
would benefit from validated small animal models. Here, we show that transgenic mice …

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu… - … and Targeted Therapy, 2021 - nature.com
Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …

The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients

A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems
worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute …