Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show that technical noise produces …
Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …
I Martic, F Papaccio, B Bellei, M Cavinato - Frontiers in Physiology, 2023 - frontiersin.org
Aging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a …
N Bobba-Alves, G Sturm, J Lin, SA Ware… - …, 2023 - Elsevier
Stress triggers anticipatory physiological responses that promote survival, a phenomenon termed allostasis. However, the chronic activation of energy-dependent allostatic responses …
Aging and age-related changes impact the quality of life (QOL) in elderly with a decline in movement, cognitive abilities and increased vulnerability towards age-related diseases …
Individuals with psychiatric disorders are at increased risk of age-related diseases and early mortality. Recent studies demonstrate that this link between mental health and aging is …
Circulating cell-free mitochondrial DNA (cf-mtDNA) is an emerging biomarker of psychobiological stress and disease which predicts mortality and is associated with various …
S Chen, X Liu, Y Li, J Wu, H Yao - arXiv preprint arXiv:2404.05613, 2024 - arxiv.org
As the aging population grows, particularly for the baby boomer generation, the United States is witnessing a significant increase in the elderly population experiencing …
CG Manole, C Soare, LC Ceafalan, VM Voiculescu - Life, 2023 - mdpi.com
The skin's recognised functions may undergo physiological alterations due to ageing, manifesting as varying degrees of facial wrinkles, diminished tautness, density, and volume …