Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …

Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …

The lack of functional vascular system in stem cell-derived cerebral organoids (COs) limits
their utility in modeling developmental processes and disease pathologies. Unlike other …

Autism spectrum disorder (ASD) includes a heterogeneous group of complex
neurodevelopmental disorders characterized by atypical behaviors with two core …

Engineered biomaterial scaffolds are becoming more prominent in research laboratories to
study drug efficacy for oncological applications in vitro, but do they have a place in …

This study offers a comprehensive overview of brain organoids for researchers. It combines
expert opinions with technical summaries on organoid definitions, characteristics, culture …

The advent of stem cell-derived cerebral organoids has already advanced our
understanding of disease mechanisms in neurological diseases. Despite this, many remain …

Mutations in the phosphatase and tensin homolog (PTEN) gene are associated with severe
neurodevelopmental disorders. Loss of PTEN leads to hyperactivation of the mechanistic …