Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

B Zeng, A Wei, Q Zhou, M Yuan, K Lei… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in
China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and …

Andrographolide and its derivatives: Current achievements and future perspectives

H Zhang, S Li, Y Si, H Xu - European Journal of Medicinal Chemistry, 2021 - Elsevier
Natural product andrographolide isolated from the plant Andrographis paniculata shows a
plethora of biological activities, including anti-tumor, anti-bacterial, anti-inflammation, anti …

Exosomal long non-coding RNAs in lung diseases

C Poulet, MS Njock, C Moermans, E Louis… - International journal of …, 2020 - mdpi.com
Within the non-coding genome landscape, long non-coding RNAs (lncRNAs) and their
secretion within exosomes are a window that could further explain the regulation, the …

Advances in traditional Chinese medicine for the treatment of chronic obstructive pulmonary disease

X Cao, Y Wang, Y Chen, M Zhao, L Liang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Chronic obstructive pulmonary disease (COPD) is the third
leading cause of death globally and thus imposes heavy economic burden on patients, their …

Andrographolide, a natural anti-inflammatory agent: An Update

X Li, W Yuan, J Wu, J Zhen, Q Sun, M Yu - Frontiers in pharmacology, 2022 - frontiersin.org
Botanicals have attracted much attention in the field of anti-inflammatory due to their good
pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient …

RETRACTED: METTL3-mediated m6A modification of ZBTB4 mRNA is involved in the smoking-induced EMT in cancer of the lung

C Cheng, Y Wu, T Xiao, J Xue, J Sun, H Xia… - … Therapy-Nucleic Acids, 2021 - cell.com
N6-methyladenosine (m6A) is an epigenetic modification associated with various tumors,
but its role in tumorigenesis remains unexplored. Here, as confirmed by methylated RNA …

EPC-exosomal miR-26a-5p improves airway remodeling in COPD by inhibiting ferroptosis of bronchial epithelial cells via PTGS2/PGE2 signaling pathway

C Liu, J Lu, T Yuan, L Xie, L Zhang - Scientific Reports, 2023 - nature.com
We aimed to investigate whether exosomes (Exo) affected chronic obstructive pulmonary
disease (COPD) by influencing ferroptosis of bronchial epithelial cells (BECs) and the …

Circ0061052 regulation of FoxC1/Snail pathway via miR-515-5p is involved in the epithelial-mesenchymal transition of epithelial cells during cigarette smoke-induced …

H Ma, L Lu, H Xia, Q Xiang, J Sun, J Xue, T Xiao… - Science of The Total …, 2020 - Elsevier
Circular RNA (circRNA) has been shown to be widely involved in a variety of lung diseases.
Cigarette smoke (CS) may induce epithelial-mesenchymal transition (EMT) of airway …

[HTML][HTML] Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK

N Kim, P Lertnimitphun, Y Jiang, H Tan, H Zhou… - Biochemical …, 2019 - Elsevier
Abstract Andrographolide (Andro), a well-known labdane diterpenoid of Andrographis
paniculata, has been reported to have anti-inflammatory effects in various inflammatory …

Advances in ameliorating inflammatory diseases and cancers by andrographolide: pharmacokinetics, pharmacodynamics, and perspective

J Qu, Q Liu, G You, L Ye, Y Jin, L Kong… - Medicinal Research …, 2022 - Wiley Online Library
Andrographolide, a well‐known natural lactone having a range of pharmacological actions
in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this …