Biomolecular machines are protein complexes that convert between different forms of free
energy. They are utilized in nature to accomplish many cellular tasks. As isothermal …

Owing to advances in genome sequencing, genome stability has become one of the most
scrutinized cellular traits across the Tree of Life. Despite its centrality to all things biological …

Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking,
or direct selection on the physicochemical cost of high fidelity. However, for many systems, it …

The translation machinery and the genes it decodes co-evolved to achieve production
throughput and accuracy. Nonetheless, translation errors are frequent, and they affect …

Many biological functions are executed by molecular machines, which like man-made
motors are powered by chemical energy, released by adenosine triphosphate hydrolysis …

Effective antibiotic use that minimizes treatment failures remains a challenge. A better
understanding of how bacterial populations respond to antibiotics is necessary. Previous …

An efficient molecular motor would deliver cargo to the target site at a high speed and in a
punctual manner while consuming a minimal amount of energy. According to a recently …

For continuous-time Markov chains and open unimolecular chemical reaction networks, we
prove that any two stationary currents are linearly related upon perturbations of a single …

Biochemistry and molecular biology rely on the recognition of structural complementarity
between molecules. Molecular interactions must be both quickly reversible, ie, tenuous, and …

Kinetic proofreading (KPR) has been used as a paradigmatic explanation for the high
specificity of ligand discrimination by cellular receptors. KPR enhances the difference in the …