Various technologies can be used to produce genome-scale, or'omics', data sets that
provide systems-level measurements for virtually all types of cellular components in a model …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Many cancer-associated genes remain to be identified to clarify the underlying molecular
mechanisms of cancer susceptibility and progression. Better understanding is also required …

This article provides an overview of principles and barriers relevant to intracellular drug and
gene transport, accumulation and retention (collectively called as drug delivery) by means of …

This paper presents a review of imaging techniques and of their utility in system biology.
During the last decade systems biology has matured into a distinct field and imaging has …

Cancer research has focused on the identification of molecular differences between
cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules …

According to Robert Weinberg (2014),“Those who have participated in cancer research
during [the last 40 years] have witnessed wild fluctuations from times where endless …

Cancer is a complex and heterogeneous disease that exhibits high levels of robustness
against various therapeutic interventions. It is a constellation of diverse and evolving …

Cancer is a highly complex disease due to the disruption of tissue architecture. Thus,
tissues, and not individual cells, are the proper level of observation for the study of …

Currently available clinico–pathologic criteria provide an imperfect assessment of outcome
for patients with advanced epithelial ovarian cancer (EOC). Identification of prognostic …