Copy number variants (CNVs) are genomic imbalances strongly linked to the aetiology of
neuropsychiatric disorders such as schizophrenia and autism. By virtue of their large size …

Unlike other medical specialties, psychiatry has not been involved in the theoretical shift that
replaced the syndromal approach with the clinico-pathological method, which consists in …

Background Postmortem studies in schizophrenia consistently show reduced dendritic
spines in the cerebral cortex but the mechanistic underpinnings of these deficits remain …

Recent studies have consistently demonstrated that the regulation of chromatin and gene
transcription plays a pivotal role in the pathogenesis of neurodevelopmental disorders …

Alzheimer's disease (AD) and schizophrenia (SCZ) represent two major neuropathological
conditions with a high disease burden. Despite their distinct etiologies, patients suffering …

Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by painful
lesions on intertriginous body areas such as the axillary, inguinal, and perianal sites. Given …

The connection and causality between cancer and neurodevelopmental disorders have
been puzzling. How can the same cellular pathways, proteins, and mutations lead to …

Background Schizophrenia (SCZ) is a severe neuropsychiatric disorder of complex, poorly
understood etiology, associated with both genetic and environmental factors. De novo …

Schizophrenia and affective disorder are two major complex mental disorders with high
heritability. Evidence shows that rare variants with significant clinical impacts contribute to …

Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular
communication. The role (s) of these vesicles have been widely investigated in the context of …