[HTML][HTML] Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

R Sartori, V Romanello, M Sandri - Nature communications, 2021 - nature.com
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

[HTML][HTML] Molecular mechanosensors in osteocytes

L Qin, W Liu, H Cao, G Xiao - Bone research, 2020 - nature.com
Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

[HTML][HTML] The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass

V Romanello, M Sandri - Cellular and Molecular Life Sciences, 2021 - Springer
The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

[HTML][HTML] Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors

H Alizadeh Pahlavani - Frontiers in endocrinology, 2022 - frontiersin.org
Sarcopenic obesity is defined as a multifactorial disease in aging with decreased body
muscle, decreased muscle strength, decreased independence, increased fat mass, due to …

[HTML][HTML] Signaling pathways that control muscle mass

A Vainshtein, M Sandri - International journal of molecular sciences, 2020 - mdpi.com
The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

[HTML][HTML] Muscle atrophy induced by mechanical unloading: mechanisms and potential countermeasures

Y Gao, Y Arfat, H Wang, N Goswami - Frontiers in physiology, 2018 - frontiersin.org
Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

[HTML][HTML] Forkhead Box O signaling pathway in skeletal muscle atrophy

K Chen, P Gao, Z Li, A Dai, M Yang, S Chen… - The American Journal of …, 2022 - Elsevier
Skeletal muscle atrophy is the consequence of protein degradation exceeding protein
synthesis because of disease, aging, and physical inactivity. Patients with skeletal muscle …

Structural and functional impairments of skeletal muscle in patients with postacute sequelae of SARS-CoV-2 infection

M Colosio, L Brocca, MF Gatti, M Neri… - Journal of Applied …, 2023 - journals.physiology.org
Following acute coronavirus disease 2019 (COVID-19), a substantial proportion of patients
showed symptoms and sequelae for several months, namely the postacute sequelae of …

Signatures of muscle disuse in spaceflight and bed rest revealed by single muscle fiber proteomics

M Murgia, S Ciciliot, N Nagaraj, C Reggiani… - PNAS …, 2022 - academic.oup.com
Astronauts experience dramatic loss of muscle mass, decreased strength, and insulin
resistance, despite performing daily intense physical exercise that would lead to muscle …