Aging can be defined as a state of progressive functional decline accompanied by an
increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and …

Skin undergoes constant self-renewal, and its functional decline is a visible consequence of
aging. Understanding human skin aging requires in-depth knowledge of the molecular and …

While the majority of cells contain a single nucleus, cell types such as trophoblasts,
osteoclasts, and skeletal myofibers require multinucleation. One advantage of …

The causes of pediatric cancers' distinctiveness compared to adult-onset tumors of the same
type are not completely clear and not fully explained by their genomes. In this study, we …

Regulation of gene expression is linked to the organization of the genome. With age,
chromatin alterations occur on all levels of genome organization, accompanied by changes …

The regulation of gene expression is a fundamental process enabling cells to respond to
internal and external stimuli or to execute developmental programs. Changes in gene …

Aging is often associated with a loss of cell type identity that results in an increase in
transcriptional noise in aged tissues. If this phenomenon reflects a fundamental property of …

This work extrapolates to humans the previous animal studies on blood heterochronicity and
establishes a novel direct measurement of biological age. Our results support the hypothesis …

Age‐related and cancer‐related epigenomic modifications have been associated with
enhanced cell‐to‐cell gene expression variability that characterizes increased cellular …

Single-cell metabolomics has the potential to reveal unique insights into intracellular
mechanisms and biological processes. However, the detection of metabolites from …