The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease

D Goldblatt, G Alter, S Crotty… - Immunological reviews, 2022 - Wiley Online Library
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …

An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

LA VanBlargan, JM Errico, PJ Halfmann, SJ Zost… - Nature medicine, 2022 - nature.com
The emergence of the highly transmissible B. 1.1. 529 Omicron variant of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is concerning for antibody …

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

PJ Halfmann, S Iida, K Iwatsuki-Horimoto, T Maemura… - Nature, 2022 - nature.com
The recent emergence of B. 1.1. 529, the Omicron variant,, has raised concerns of escape
from protection by vaccines and therapeutic antibodies. A key test for potential …

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

TN Starr, N Czudnochowski, Z Liu, F Zatta, YJ Park… - Nature, 2021 - nature.com
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape,–, have activity
against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

YM Loo, PM McTamney, RH Arends… - Science translational …, 2022 - science.org
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines, there remains a need for more prevention and treatment options for individuals …

After the pandemic: perspectives on the future trajectory of COVID-19

A Telenti, A Arvin, L Corey, D Corti, MS Diamond… - Nature, 2021 - nature.com
There is a realistic expectation that the global effort in vaccination will bring the pandemic
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) under control …

The humoral response and antibodies against SARS-CoV-2 infection

H Qi, B Liu, X Wang, L Zhang - Nature Immunology, 2022 - nature.com
Two and a half years into the COVID-19 pandemic, we have gained many insights into the
human antibody response to the causative SARS-CoV-2 virus. In this Review, we …

Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …