Human disease models in drug development

A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Sex in cardiovascular disease: Why this biological variable should be considered in in vitro models

AK McClain, PP Monteleone, J Zoldan - Science Advances, 2024 - science.org
Cardiovascular disease (CVD), the world's leading cause of death, exhibits notable
epidemiological, clinical, and pathophysiological differences between sexes. Many such …

Sex differences in heart: from basics to clinics

C Prajapati, J Koivumäki, M Pekkanen-Mattila… - European Journal of …, 2022 - Springer
Sex differences exist in the structure and function of human heart. The patterns of ventricular
repolarization in normal electrocardiograms (ECG) differ in men and women: men ECG …

Sex as a biological variable in tissue engineering and regenerative medicine

JB Allen, C Ludtka, BD James - Annual review of biomedical …, 2023 - annualreviews.org
Although sex differences have been noted in cellular function and behavior, therapy efficacy,
and disease incidence and outcomes, the adoption of sex as a biological variable in tissue …

Emerging technologies for cardiac tissue engineering and artificial hearts

L Sun, Y Wang, D Xu, Y Zhao - Smart Medicine, 2023 - Wiley Online Library
Heart diseases, especially cardiovascular diseases, have brought heavy burden on society
for their high morbidity and mortality. In clinical, heart transplantation is recognized as an …

Engineering stem cell therapeutics for cardiac repair

J Fang, JJ Li, X Zhong, Y Zhou, RJ Lee… - Journal of Molecular and …, 2022 - Elsevier
Cardiovascular disease is the leading cause of death in the world. Stem cell-based
therapies have been widely investigated for cardiac regeneration in patients with heart …

[HTML][HTML] Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics

P Gil-Cabrerizo, T Simon-Yarza, E Garbayo… - Advanced Drug Delivery …, 2024 - Elsevier
Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …

[HTML][HTML] Female cardiovascular biology and resilience in the setting of physiological and pathological stress

HE Collins - Redox Biology, 2023 - Elsevier
For years, females were thought of as smaller men with complex hormonal cycles; as a
result, females have been largely excluded from preclinical and clinical research. However …

Sex matters: the frequently overlooked importance of considering sex in computational models

KS Burrowes, M Ruppage, A Lowry, D Zhao - Frontiers in Physiology, 2023 - frontiersin.org
Personalised medicine and the development of a virtual human or a digital twin comprises
visions of the future of medicine. To realise these innovations, an understanding of the …

Sex differences in radiation research

LP Taliaferro, RK Agarwal, CN Coleman, AL DiCarlo… - 2024 - Taylor & Francis
Abstract Purpose The Sex Differences in Radiation Research workshop addressed the role
of sex as a confounder in radiation research and its implication in real-world radiological …