Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

Crop production is the primary goal of agricultural activities, which is always taken into
consideration. However, global agricultural systems are coming under increasing pressure …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for
interpreting disease-associated variants, and context-specific QTLs show particular …

Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA
methylation changes in genetic predisposition, yet they have not been fully characterized in …

Most studies aiming to identify epigenetic biomarkers do so from complex tissues that are
composed of many different cell-types. By definition, these cell-types vary substantially in …

Abstract The Infinium BeadChip is the most widely used DNA methylome assay technology
for population-scale epigenome profiling. However, the standard workflow requires over 200 …

Stress has been consistently linked to negative impacts on physical and mental health. More
specifically, patients with chronic pain experience stress intolerance, which is an …

Epigenetic changes are required for normal development, yet the nature and respective
contribution of factors that drive epigenetic variation in humans remain to be fully …