Background Expression quantitative trait loci (eQTL) studies show how genetic variants
affect downstream gene expression. Single-cell data allows reconstruction of personalized …

Biological systems respond to perturbations through the rewiring of molecular interactions,
organised in gene regulatory networks (GRNs). Among these, the increasingly high …

Cleft lip+/-cleft palate (CL/P) is one of the most common birth defects. Although research has
identified multiple genetic risk loci for different types of CL/P (ie, syndromic or non-syndromic …

Background Immune cells play a major role in the pathogenesis of COPD. Changes in the
distribution and cellular functions of major immune cells, such as alveolar macrophages …

In Populus, drought is a major problem affecting plant growth and development which can
be closely reflected by corresponding transcriptomic changes. Nevertheless, how these …

We integrated genomic and bioinformatic analyses, using data from the largest genome-
wide association study of cocaine dependence (CD; n= 6546; 82.37% with CD; 57.39 …

The development of hair follicle in cashmere goats shows significant periodic change, as
with mice and humans. However, for cashmere goat with double-coat, the periodic change …

Leishmania is a unicellular protozoan that has a limited transcriptional control and mostly
uses post-transcriptional regulation of gene expression, although the molecular …

Understanding the causal processes that contribute to disease onset and progression is
essential for developing novel therapies. Although trans-acting expression quantitative trait …

Background Network-based analysis of gene expression through co-expression networks
can be used to investigate modular relationships occurring between genes performing …