Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …

Cognitive abilities, including general intelligence and domain-specific abilities such as fluid
reasoning, comprehension knowledge, working memory capacity, and processing speed …

Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization.
Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown …

Theories of adult cognitive development classically distinguish between fluid abilities, which
require effortful processing at the time of assessment, and crystallized abilities, which …

Background and Objectives To investigate chronic inflammation in relation to cognitive
aging by comparison of an epigenetic and serum biomarker of C-reactive protein and their …

Biologically based senescence processes and cumulative opportunities for experience
collectively give rise to profound changes in cognition in later adulthood, the trajectories of …

With the long-standing amyloid cascade hypothesis (ACH) largely discredited, there is an
acute need for a new all-encompassing interpretation of Alzheimer's disease (AD). Whereas …

Many believe that engaging in novel and mentally challenging activities promotes brain
health and prevents Alzheimer's disease in later life. However, mental stimulation may also …

Objectives Age-related cognitive changes can be influenced by both brain maintenance
(BM), which refers to the relative absence over time of changes in neural resources or …