Recent advancements in single-cell technologies have enabled expression quantitative trait
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …

Evidence suggests that innate and adaptive cellular responses mediate resistance to the
influenza virus and confer protection after vaccination. However, few studies have resolved …

Humans exhibit considerable variability in their immune responses to the same immune
challenges. Such variation is widespread and affects individual and population‐level …

Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …

Understanding the consequences of individual transcriptome variation is fundamental to
deciphering human biology and disease. We implement a statistical framework to quantify …

The segmented RNA genome of influenza A viruses (IAVs) enables viral evolution through
genetic reassortment after multiple IAVs coinfect the same cell, leading to viruses harboring …

Influenza virus infections are thought to be initiated in a small number of cells; however, the
heterogeneity across the cellular responses of the epithelial cells during establishment of …

Influenza A virus (IAV) infections are frequent every year and result in a range of disease
severity. Here, we wanted to explore the potential contribution of transposable elements …

Analysis of pre-existing immunity and its effects on acute infection often focus on memory
responses associated with a prior infectious exposure. However, memory responses occur …

Prior studies have identified genetic, infectious, and biological associations with immune
competence and disease severity; however, there have been few integrative analyses of …