Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result
from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age …

People who experience trauma and develop posttraumatic stress disorder (PTSD) are at
increased risk for poor health. One mechanism that could explain this risk is accelerated …

Abstract Background Essential trace elements (ETEs) play essential roles in vital functions,
but their effects on epigenetic aging remain poorly understood. Objectives This study aimed …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Growing evidence suggests that social relationship quality can influence age-related health
outcomes, although how the quality of one's relationships directly relates to the underlying …

Background Epigenetic age is an estimator of biological age based on DNA methylation; its
discrepancy from chronologic age warrants further investigation. We recently reported that …