Development of multi epitope subunit vaccines against emerging carp viruses Cyprinid herpesvirus 1 and 3 using immunoinformatics approach
NA Rani, TB Robin, AA Prome, N Ahmed, AT Moin… - Scientific Reports, 2024 - nature.com
Cyprinid herpesvirus is a causative agent of a destructive disease in common and koi carp
(Cyprinus carpio), which leads to substantial global financial losses in aquaculture …
(Cyprinus carpio), which leads to substantial global financial losses in aquaculture …
Immunoinformatics approach to design novel subunit vaccine against the Epstein-Barr virus
Epstein-Barr virus (EBV) is a lymphotropic virus responsible for numerous epithelial and
lymphoid cell malignancies, including gastric carcinoma, Hodgkin's lymphoma …
lymphoid cell malignancies, including gastric carcinoma, Hodgkin's lymphoma …
Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B
Ras is a key member in the superfamily of small GTPase. Transforming between GTP-bound
active state and GDP-bound inactive state in response to exogenous signals, Ras serves as …
active state and GDP-bound inactive state in response to exogenous signals, Ras serves as …
Autopromotion of K-Ras4B feedback activation through an SOS-mediated long-range allosteric effect
X He, K Du, Y Wang, J Fan, M Li, D Ni, S Lu… - Frontiers in Molecular …, 2022 - frontiersin.org
The Ras-specific guanine nucleotide exchange factors Son of Sevenless (SOS) regulates
Ras activation by converting inactive GDP-bound to active GTP-bound states. The catalytic …
Ras activation by converting inactive GDP-bound to active GTP-bound states. The catalytic …
Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level …
RR Wang, WS Liu, L Zhou, Y Ma… - Journal of Biomolecular …, 2019 - Taylor & Francis
The over-activation of Ras/mitogen-activated protein kinase (MAPK) signaling pathway
associated with a variety of cancers is usually related with abnormal activation of Src …
associated with a variety of cancers is usually related with abnormal activation of Src …
Revealing binding selectivity of inhibitors toward bromodomain-containing proteins 2 and 4 using multiple short molecular dynamics simulations and free energy …
LF Wang, Y Wang, ZY Yang, J Zhao… - SAR and QSAR in …, 2020 - Taylor & Francis
Emerging evidences indicate bromodomain-containing proteins 2 and 4 (BRD2 and BRD4)
play critical roles in cancers, inflammations, cardiovascular diseases and other pathologies …
play critical roles in cancers, inflammations, cardiovascular diseases and other pathologies …
In vitro and in silico investigation of effects of antimicrobial peptides from Solanaceae plants against rice sheath blight pathogen Rhizoctinia solani
Rhizoctonia solani, the causative agent of sheath blight disease in rice, poses a significant
threat to agricultural productivity. Traditional management approaches involving chemical …
threat to agricultural productivity. Traditional management approaches involving chemical …
Microsecond molecular dynamics simulations reveal the allosteric regulatory mechanism of p53 R249S mutation in p53-associated liver cancer
X Liu, W Tian, J Cheng, D Li, T Liu, L Zhang - Computational biology and …, 2020 - Elsevier
The tumor suppressor p53, a transcription factor, plays a critical role in many cellular
processes, including DNA repair and apoptosis and cell cycle arrest. Missense mutations in …
processes, including DNA repair and apoptosis and cell cycle arrest. Missense mutations in …
How does the novel T315L mutation of breakpoint cluster region-abelson (BCR-ABL) kinase confer resistance to ponatinib: a comparative molecular dynamics …
Acute lymphocytic leukemia (ALL) is one of the most dangerous types of leukemia, and
about 40% of them is Philadelphia chromosome-positive acute lymphocytic leukemia (Ph+ …
about 40% of them is Philadelphia chromosome-positive acute lymphocytic leukemia (Ph+ …
Mechanistic influence of discreet conformation of human telomerase linker region
Approximately 90% of malignancies have been shown to have human telomerase activity,
establishing it as a viable therapeutic target. The crystal structure of telomerase was …
establishing it as a viable therapeutic target. The crystal structure of telomerase was …