Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

Pluripotent stem cells hold great promise in regenerative medicine and developmental
biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

No longer viewed as a metabolic waste product and cause of muscle fatigue, a
contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …

Key pathological, including oncogenic, signaling pathways regulate the canonical functions
of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling …

In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-
enter the cell cycle and proliferate. To proliferate, cells must increase their uptake and …

The growing field of tumor metabolism has greatly expanded our knowledge of metabolic
reprogramming in cancer. Apart from their established roles, various metabolic enzymes and …