Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
In-host mathematical modelling of COVID-19 in humans
EA Hernandez-Vargas, JX Velasco-Hernandez - Annual reviews in control, 2020 - Elsevier
COVID-19 pandemic has underlined the impact of emergent pathogens as a major threat to
human health. The development of quantitative approaches to advance comprehension of …
human health. The development of quantitative approaches to advance comprehension of …
[HTML][HTML] Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3 …
F Ader, M Bouscambert-Duchamp, M Hites… - The Lancet infectious …, 2022 - thelancet.com
Background The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial.
We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with …
We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with …
Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness
The dynamics of SARS-CoV-2 replication and shedding in humans remain poorly
understood. We captured the dynamics of infectious virus and viral RNA shedding during …
understood. We captured the dynamics of infectious virus and viral RNA shedding during …
[HTML][HTML] ESCMID COVID-19 living guidelines: drug treatment and clinical management
M Bartoletti, O Azap, A Barac, L Bussini… - Clinical microbiology …, 2022 - Elsevier
Abstract Scope In January 2021, the ESCMID Executive Committee decided to launch a new
initiative to develop ESCMID guidelines on several COVID-19-related issues, including …
initiative to develop ESCMID guidelines on several COVID-19-related issues, including …
The total number and mass of SARS-CoV-2 virions
Quantitatively describing the time course of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for …
coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for …
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort
N Néant, G Lingas, Q Le Hingrat… - Proceedings of the …, 2021 - National Acad Sciences
The characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viral kinetics in hospitalized patients and its association with mortality is unknown. We …
viral kinetics in hospitalized patients and its association with mortality is unknown. We …
No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected …
M Mahévas, VT Tran, M Roumier, A Chabrol, R Paule… - medrxiv, 2020 - medrxiv.org
Background Treatments are urgently needed to prevent respiratory failure and deaths from
coronavirus disease 2019 (COVID-19). Hydroxychloroquine (HCQ) has received worldwide …
coronavirus disease 2019 (COVID-19). Hydroxychloroquine (HCQ) has received worldwide …
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness
The relationship between SARS-CoV-2 viral load and infectiousness is poorly known. Using
data from a cohort of cases and high-risk contacts, we reconstructed viral load at the time of …
data from a cohort of cases and high-risk contacts, we reconstructed viral load at the time of …
Predicted occurrence, ecotoxicological risk and environmentally acquired resistance of antiviral drugs associated with COVID-19 in environmental waters
Antiviral drugs have been used to treat the ever-growing number of coronavirus disease,
2019 (COVID-19) patients. Consequently, unprecedented amounts of such drug residues …
2019 (COVID-19) patients. Consequently, unprecedented amounts of such drug residues …