Background Chromatin contacts are essential for gene-expression regulation; however,
obtaining a high-resolution genome-wide chromatin contact map is still prohibitively …

Multiplexed DNA fluorescence in situ hybridization (FISH) imaging technologies have been
developed to map the folding of chromatin fibers at tens of nanometers and up to several …

Background Interactions among topologically associating domains (TADs), and between the
nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape …

Higher-order genomic structures play a critical role in regulating gene expression by
influencing the spatial proximity of promoters and enhancers. Live-cell imaging studies have …

Traditionally, the field of genomics has been studied from a biochemical perspective.
Besides chemical influences, cells are subject to a variety of mechanical signals from their …

The Hi-C method has revolutionized the study of genome organization, yet interpretation of
Hi-C interaction frequency maps remains a major challenge. Genomic compartments are a …

Enhancers possess both structural elements mediating promoter looping and functional
elements mediating gene expression. Traditional models of enhancer-mediated gene …

Abstract Human Accelerated Regions (HARs) are highly conserved across species but
exhibit a significant excess of human-specific sequence changes, suggesting they may have …

The trithorax protein ASH2L is essential for organismal and tissue development. As a
subunit of COMPASS/KMT2 complexes, ASH2L is necessary for methylation of histone H3 …

With the development of chromosome conformation capture technology, the genome-wide
investigation of higher-order chromatin structure by using high-throughput chromatin …