Multimaterial 3D printing of highly stretchable silicone elastomers

L Zhou, Q Gao, J Fu, Q Chen, J Zhu… - ACS applied materials …, 2019 - ACS Publications
3D printing of silicone elastomers with the direct ink writing (DIW) process has demonstrated
great potential in areas as diverse as flexible electronics, medical devices, and soft robotics …

Breakthroughs and applications of organ-on-a-chip technology

MC Koyilot, P Natarajan, CR Hunt, S Sivarajkumar… - Cells, 2022 - mdpi.com
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

3D printed drug delivery and testing systems—a passing fad or the future?

SH Lim, H Kathuria, JJY Tan, L Kang - Advanced drug delivery reviews, 2018 - Elsevier
Abstract The US Food and Drug Administration approval of the first 3D printed tablet in 2015
has ignited growing interest in 3D printing, or additive manufacturing (AM), for drug delivery …

Molecular mechanisms of arrhythmogenic cardiomyopathy

KM Austin, MA Trembley, SF Chandler… - Nature Reviews …, 2019 - nature.com
Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-
threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial …

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

E Giacomelli, M Bellin, L Sala, BJ Van Meer… - …, 2017 - journals.biologists.com
Cardiomyocytes and endothelial cells in the heart are in close proximity and in constant
dialogue. Endothelium regulates the size of the heart, supplies oxygen to the myocardium …

[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening

H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Induced pluripotent stem cells 10 years later: for cardiac applications

Y Yoshida, S Yamanaka - Circulation research, 2017 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …

[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

U Marx, TB Andersson, A Bahinski, M Beilmann… - Altex, 2016 - ncbi.nlm.nih.gov
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

Differentiation of cardiomyocytes and generation of human engineered heart tissue

K Breckwoldt, D Letuffe-Brenière, I Mannhardt… - Nature protocols, 2017 - nature.com
Since the advent of the generation of human induced pluripotent stem cells (hiPSCs),
numerous protocols have been developed to differentiate hiPSCs into cardiomyocytes and …

Organ‐on‐a‐Chip Systems: microengineering to biomimic living systems

F Zheng, F Fu, Y Cheng, C Wang, Y Zhao, Z Gu - Small, 2016 - Wiley Online Library
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …