Biomimetic nanoparticles coated with bacterial outer membrane vesicles as a new-generation platform for biomedical applications

A Naskar, H Cho, S Lee, K Kim - Pharmaceutics, 2021 - mdpi.com
The biomedical field is currently reaping the benefits of research on biomimetic
nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular …

Integrated mass spectrometry-based multi-omics for elucidating mechanisms of bacterial virulence

L Man, WP Klare, AL Dale, JA Cain… - Biochemical Society …, 2021 - portlandpress.com
Despite being considered the simplest form of life, bacteria remain enigmatic, particularly in
light of pathogenesis and evolving antimicrobial resistance. After three decades of …

Proteomic profiling reveals distinct bacterial extracellular vesicle subpopulations with possibly unique functionality

HM McMillan, MJ Kuehn - Applied and Environmental …, 2023 - Am Soc Microbiol
Bacterial outer membrane vesicles (OMVs) are 20-to 200-nm secreted packages of lipids,
small molecules, and proteins that contribute to diverse bacterial processes. In plant …

Francisella tularensis Outer Membrane Vesicles Participate in the Early Phase of Interaction With Macrophages

I Pavkova, J Klimentova, J Bavlovic… - Frontiers in …, 2021 - frontiersin.org
Francisella tularensis is known to release unusually shaped tubular outer membrane
vesicles (OMV) containing a number of previously identified virulence factors and …

Spatial Proteomics Reveals Differences in the Cellular Architecture of Antibody-Producing CHO and Plasma Cell–Derived Cells

R Kretz, L Walter, N Raab, N Zeh, R Gauges… - Molecular & Cellular …, 2022 - ASBMB
Most of the recombinant biotherapeutics employed today to combat severe illnesses, for
example, various types of cancer or autoimmune diseases, are produced by Chinese …

[HTML][HTML] Intact O-antigen is critical structure for the exceptional tubular shape of outer membrane vesicles in Francisella tularensis

J Bavlovic, I Pavkova, L Balonova, O Benada… - Microbiological …, 2023 - Elsevier
Francisella tularensis is a highly infectious Gram-negative coccobacillus which causes the
disease tularemia. The potential for its misuse as a biological weapon has led disease …

Protective potential of outer membrane vesicles derived from a virulent strain of Francisella tularensis

I Pavkova, J Bavlovic, K Kubelkova, J Stulik… - Frontiers in …, 2024 - frontiersin.org
Francisella tularensis secretes tubular outer membrane vesicles (OMVs) that contain a
number of immunoreactive proteins as well as virulence factors. We have reported …

[HTML][HTML] Epigallocatechin gallate inhibits Francisella tularensis growth and suppresses the function of DNA-binding protein HU

P Pavlik, P Jost, P Rehulka, V Vozandychova… - Microbial …, 2023 - Elsevier
Francisella tularensis is a highly infectious intracellular bacterium causing tularemia disease
and is regarded as a potential biological weapon. The development of a vaccine, effective …

Characterization of the Outer Membrane Vesicles of Pseudomonas aeruginosa Exhibiting Growth Inhibition against Acinetobacter baumannii

JW Suh, JS Kang, JY Kim, SB Kim, YK Yoon, JW Sohn - Biomedicines, 2024 - mdpi.com
We investigated the Pseudomonas aeruginosa (PA) outer membrane vesicles (OMVs) and
their effect on Acinetobacter baumannii (AB) growth in vitro. The inhibitory effects of PA on …

Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours

Y Ge, F Sun, B Zhao, F Kong, Z Li, X Kong - Frontiers in Oncology, 2023 - frontiersin.org
Extracellular vesicles are fundamentally significant in the communication between cells.
Outer Membrane Vesicles (OMVs) are a special kind of EVs produced by Gram-negative …