Clinical pharmacokinetics and pharmacodynamics of clopidogrel
Acute coronary syndromes (ACS) remain life-threatening disorders, which are associated
with high morbidity and mortality. Dual antiplatelet therapy with aspirin and clopidogrel has …
with high morbidity and mortality. Dual antiplatelet therapy with aspirin and clopidogrel has …
Bleeding avoidance strategies: consensus and controversy
HL Dauerman, SV Rao, FS Resnic… - Journal of the American …, 2011 - jacc.org
Bleeding complications after coronary intervention are associated with prolonged
hospitalization, increased hospital costs, patient dissatisfaction, morbidity, and 1-year …
hospitalization, increased hospital costs, patient dissatisfaction, morbidity, and 1-year …
Cytochrome 2C19* 17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
D Sibbing, W Koch, D Gebhard, T Schuster, S Braun… - Circulation, 2010 - Am Heart Assoc
Background—The cytochrome P450 (CYP) 2C19 isoenzyme plays an important role in
clopidogrel metabolization. A recently explored CYP2C19* 17 allelic variant has been linked …
clopidogrel metabolization. A recently explored CYP2C19* 17 allelic variant has been linked …
[HTML][HTML] Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement
D Sibbing, S Schulz, S Braun, T Morath… - Journal of Thrombosis …, 2010 - Elsevier
Background: In patients undergoing percutaneous coronary intervention (PCI), a link
between bleeding and excess mortality has been demonstrated. A potential association of …
between bleeding and excess mortality has been demonstrated. A potential association of …
The prognostic importance of left ventricular function in patients with ST-segment elevation myocardial infarction: the HORIZONS-AMI trial
VG Ng, AJ Lansky, S Meller… - … Heart Journal: Acute …, 2014 - academic.oup.com
Aim Left ventricular (LV) dysfunction during and after hospitalization for ST-segment
elevation myocardial infarction (STEMI) is associated with increased mortality. Whether …
elevation myocardial infarction (STEMI) is associated with increased mortality. Whether …
Self-regulated hirudin delivery for anticoagulant therapy
Pathological coagulation, a disorder of blood clotting regulation, induces a number of
cardiovascular diseases. A safe and efficient system for the delivery of anticoagulants to …
cardiovascular diseases. A safe and efficient system for the delivery of anticoagulants to …
LDL cholesterol levels and in-hospital bleeding in patients on high-intensity antithrombotic therapy: findings from the CCC-ACS project
Q Yang, D Sun, C Pei, Y Zeng, Z Wang… - European Heart …, 2021 - academic.oup.com
Aims Emerging evidence has linked cholesterol metabolism with platelet responsiveness.
We sought to examine the dose–response relationship between low-density lipoprotein …
We sought to examine the dose–response relationship between low-density lipoprotein …
Platelet biology and response to antiplatelet therapy in women: implications for the development and use of antiplatelet pharmacotherapies for cardiovascular disease
TY Wang, DJ Angiolillo, M Cushman… - Journal of the American …, 2012 - jacc.org
Women are underrepresented in cardiovascular studies, even as their preponderance in the
aging population steadily increases. Although concerns have been raised about the …
aging population steadily increases. Although concerns have been raised about the …
Individual variability in the disposition of and response to clopidogrel: pharmacogenomics and beyond
HG Xie, JJ Zou, ZY Hu, JJ Zhang, F Ye… - Pharmacology & …, 2011 - Elsevier
The widespread use of clopidogrel alone or in combination with aspirin has significantly
benefited patients with acute coronary syndrome who are managed medically or by …
benefited patients with acute coronary syndrome who are managed medically or by …
Bivalirudin vs. unfractionated heparin during percutaneous coronary interventions in patients with stable and unstable angina pectoris: 1-year results of the ISAR …
S Schulz, J Mehilli, G Ndrepepa… - European heart …, 2010 - academic.oup.com
Abstract Aims In ISAR-REACT 3, 30-day outcomes in 4570 biomarker negative patients
undergoing percutaneous coronary intervention (PCI)≥ 2 h after pre-treatment with 600 mg …
undergoing percutaneous coronary intervention (PCI)≥ 2 h after pre-treatment with 600 mg …