Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

NC Sondermann, S Faßbender, F Hartung… - Biochemical …, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets

S Haid, A Matthaei, M Winkler, SM Sake… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Libraries composed of licensed drugs represent a vast repertoire of molecules modulating
physiological processes in humans, providing unique opportunities for the discovery of host …

Light Sensing beyond Vision: Focusing on a Possible Role for the FICZ/AhR Complex in Skin Optotransduction

T Guarnieri - Cells, 2024 - mdpi.com
Although our skin is not the primary visual organ in humans, it acts as a light sensor, playing
a significant role in maintaining our health and overall well-being. Thanks to the presence of …

Short‐term exposure to ambient air pollution and COVID‐19 severity during SARS‐CoV‐2 Delta and Omicron waves: A multicenter study

B Poniedziałek, P Rzymski… - Journal of Medical …, 2023 - Wiley Online Library
Air pollution may affect the clinical course of respiratory diseases, including COVID‐19. This
study aimed to evaluate the relationship between exposure of adult patients to mean 24 h …

In vitro evaluation of antiviral activities of funicone-like compounds vermistatin and penisimplicissin against canine coronavirus infection

C Cerracchio, MM Salvatore, L Del Sorbo, F Serra… - Antibiotics, 2023 - mdpi.com
Recent studies have demonstrated that 3-O-methylfunicone (OMF), a fungal secondary
metabolite from Talaromyces pinophilus belonging to the class of funicone-like compounds …

Canine coronavirus activates aryl hydrocarbon receptor during in vitro infection

C Cerracchio, F Serra, MG Amoroso, F Fiorito - Viruses, 2022 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts
with substrates, including microbial metabolites. Recent advances reveal that AhR is …

Effectiveness of the Fungal Metabolite 3-O-Methylfunicone towards Canine Coronavirus in a Canine Fibrosarcoma Cell Line (A72)

C Cerracchio, V Iovane, MM Salvatore, MG Amoroso… - Antibiotics, 2022 - mdpi.com
Canine coronavirus (CCoV), an alphacoronavirus, may cause self-limiting enteric disease in
dogs, especially in puppies. The noteworthy plasticity of coronaviruses (CoVs) occurs …

Diminazene aceturate attenuates systemic inflammation via microbiota gut-5-HT brain-spleen sympathetic axis in male mice

P Passaglia, A Kanashiro, HB Silva… - Brain, Behavior, and …, 2024 - Elsevier
The sympathetic arm of the inflammatory reflex is the efferent pathway through which the
central nervous system (CNS) can control peripheral immune responses. Diminazene …

Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases

AY Grishanova, ML Perepechaeva - International Journal of Molecular …, 2024 - mdpi.com
Persistent systemic chronic inflammatory conditions are linked with many pathologies,
including cardiovascular diseases (CVDs), a leading cause of death across the globe …

[HTML][HTML] Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19

Y Yao, ZJ Liu, YK Zhang, HJ Sun - World Journal of …, 2022 - ncbi.nlm.nih.gov
The global coronavirus disease 2019 (COVID-19) has become one of the biggest threats to
the world since 2019. The respiratory and gastrointestinal tracts are the main targets for …