Type I and type II alveolar epithelial cells (AECs) are derived from the same progenitor cell,
but little is known about the factors that regulate their differentiation into separate …

With the worldwide obesity epidemic, the proportion of women entering pregnancy
overweight or obese has increased significantly in recent years. Babies born to obese …

Objective: The aim of this study was to determine the effects of intrauterine growth restriction
on fetal lung liquid and lung development. Study Design: Intrauterine growth restriction was …

The lung develops before birth as a collapsible, liquid‐filled, organ. Throughout the later
stages of gestation the fetal lungs are maintained at a level of expansion that is considerably …

Objectives Infants with congenital diaphragmatic hernia (CDH) are predisposed to
pulmonary hypertension after birth, owing to lung hypoplasia that impairs fetal pulmonary …

Fetal breathing movements (FBM) are necessary for fetal lung growth and maturation. The
authors analyzed fetal rat lungs cultured with or without lung distension and tracheal …

In utero tracheal occlusion (TO) is a potent stimulus of fetal lung growth, and is currently
being applied in clinical trials to treat severe forms of pulmonary hypoplasia. The aim of this …

We determined the effects of sustained and cyclical prenatal mechanical strain on the
hypoplastic lung of the ovine model of congenital diaphragmatic hernia. Over a period of 4 …

Our aim was to determine whether an existing lung growth deficit could be reversed, in
utero, by short-term (6 d) obstruction of the fetal trachea. Chronically catheterized fetal sheep …

It was previously shown that tracheal obstruction accelerated fetal lung growth and
eventually reversed the pulmonary hypoplasia in experimental diaphragmatic hernia. We …