Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

It is widely known that the liver is a central organ in lipogenesis, gluconeogenesis and
cholesterol metabolism. However, over the last decades, a variety of pathological conditions …

Lipid droplets (LDs) are dynamic, cytosolic lipid‐storage organelles found in nearly all cell
types. Too many or too few LDs during excess or deficient fat storage lead to many different …

The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose
differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3–12, and …

Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all
aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of …

Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated
transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master …

The endoplasmic reticulum (ER) is the cellular organelle responsible for protein folding and
assembly, lipid and sterol biosynthesis, and calcium storage. The unfolded protein response …

Peroxisome proliferator‐activated receptor (PPAR) γ is a nuclear receptor central to glucose
and lipid homeostasis. PPARγ role in nonalcoholic fatty liver disease is controversial …