The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies

SR Alli, I Gorbovskaya, JCW Liu, NJ Kolla… - International journal of …, 2022 - mdpi.com
An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …

Overlapping mechanisms of action of brain-active bacteria and bacterial metabolites in the pathogenesis of common brain diseases

TP Eicher, MH Mohajeri - Nutrients, 2022 - mdpi.com
The involvement of the gut microbiota and the metabolites of colon-residing bacteria in brain
disease pathogenesis has been covered in a growing number of studies, but comparative …

The role of gut dysbiosis in the pathophysiology of neuropsychiatric disorders

N Anand, VR Gorantla, SB Chidambaram - Cells, 2022 - mdpi.com
Mounting evidence shows that the complex gut microbial ecosystem in the human
gastrointestinal (GI) tract regulates the physiology of the central nervous system (CNS) via …

Mechanistic insights into the link between gut dysbiosis and major depression: an extensive review

S Sonali, B Ray, H Ahmed Tousif, AG Rathipriya… - Cells, 2022 - mdpi.com
Depression is a highly common mental disorder, which is often multifactorial with sex,
genetic, environmental, and/or psychological causes. Recent advancements in biomedical …

Neurodegenerative and neurodevelopmental diseases and the gut-brain axis: The potential of therapeutic targeting of the microbiome

B Bicknell, A Liebert, T Borody, G Herkes… - International journal of …, 2023 - mdpi.com
The human gut microbiome contains the largest number of bacteria in the body and has the
potential to greatly influence metabolism, not only locally but also systemically. There is an …

[HTML][HTML] Acute sleep deprivation exacerbates systemic inflammation and psychiatry disorders through gut microbiota dysbiosis and disruption of circadian rhythms

DF Yang, WC Huang, CW Wu, CY Huang… - Microbiological …, 2023 - Elsevier
Acute sleep deprivation (ASD) is often observed in shift workers and characterized by
drowsiness and unrelenting exhaustion. The physiological and psychological effects of ASD …

A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide …

J Zhang, L Ma, L Chang, Y Pu, Y Qu… - Translational …, 2020 - nature.com
The vagus nerve plays a role in the cross talk between the brain and gut microbiota, which
could be involved in depression. The subdiaphragmatic vagus nerve serves as a major …

Bacterial metabolites of human gut microbiota correlating with depression

OV Averina, YA Zorkina, RA Yunes, AS Kovtun… - International journal of …, 2020 - mdpi.com
Depression is a global threat to mental health that affects around 264 million people
worldwide. Despite the considerable evolution in our understanding of the pathophysiology …

Gut microbiota in anxiety and depression: unveiling the relationships and management options

A Kumar, J Pramanik, N Goyal, D Chauhan… - Pharmaceuticals, 2023 - mdpi.com
The gut microbiota is critical for maintaining human health and the immunological system.
Several neuroscientific studies have shown the significance of microbiota in developing …

5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption

J Ma, R Wang, Y Chen, Z Wang, Y Dong - Journal of Neuroinflammation, 2023 - Springer
Background The microbiota–gut–brain axis plays an important role in the development of
depression. The aim of this study was to investigate the effects of 5-HT on cognitive function …