Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder

SE Bergen, CT O'dushlaine, S Ripke, PH Lee… - Molecular …, 2012 - nature.com
Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders
with overlapping susceptibility loci and symptomatology. We conducted a genome-wide …

Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review

DP Prata, B Costa-Neves, G Cosme… - Journal of psychiatric …, 2019 - Elsevier
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

[PDF][PDF] Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

RJL Anney, A Avbersek, D Balding, L Baum… - The Lancet …, 2014 - hub.hku.hk
Background The epilepsies are a clinically heterogeneous group of neurological disorders.
Despite strong evidence for heritability, genome-wide association studies have had little …

[HTML][HTML] The major histocompatibility complex (MHC) in schizophrenia: a review

R Mokhtari, HM Lachman - Journal of clinical & cellular …, 2016 - ncbi.nlm.nih.gov
Epidemiological studies and mouse models suggest that maternal immune activation,
induced clinically through prenatal exposure to one of several infectious diseases, is a risk …

The integrated landscape of causal genes and pathways in schizophrenia

C Ma, C Gu, Y Huo, X Li, XJ Luo - Translational psychiatry, 2018 - nature.com
Genome-wide association studies (GWAS) have identified more than 100 loci that show
robust association with schizophrenia risk. However, due to the complexity of linkage …

The emerging roles of TCF4 in disease and development

MP Forrest, MJ Hill, AJ Quantock… - Trends in molecular …, 2014 - cell.com
Genome-wide association studies have identified common variants in transcription factor 4
(TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and …

Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: a genome-wide association study and meta-analysis

HJ Li, C Zhang, L Hui, DS Zhou, Y Li, CY Zhang… - JAMA …, 2021 - jamanetwork.com
Importance The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully
understood. Objective To explore the genetic basis of BD in the Han Chinese population …

Genetic generalized epilepsies

SA Mullen, SF Berkovic, ILAE Genetics Commission… - …, 2018 - Wiley Online Library
The genetic generalized epilepsies (GGEs) are mainly genetically determined disorders.
Although inheritance in most cases appears to be complex, involving multiple genes …

The anorexia nervosa genetics initiative (ANGI): overview and methods

LM Thornton, MA Munn-Chernoff, JH Baker… - Contemporary Clinical …, 2018 - Elsevier
Background Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide
significant locus has been identified. We describe methods and procedures for the Anorexia …

SZDB: a database for schizophrenia genetic research

Y Wu, YG Yao, XJ Luo - Schizophrenia bulletin, 2017 - academic.oup.com
Schizophrenia (SZ) is a debilitating brain disorder with a complex genetic architecture.
Genetic studies, especially recent genome-wide association studies (GWAS), have identified …