A systematic review of genome-wide research on psychotic experiences and negative symptom traits: new revelations and implications for psychiatry
We present a systematic review of genome-wide research on psychotic experience and
negative symptom (PENS) traits in the community. We integrate these new findings, most of …
negative symptom (PENS) traits in the community. We integrate these new findings, most of …
Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors
J Santos‐Terra, I Deckmann… - International Journal …, 2021 - Wiley Online Library
Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of
psychiatric conditions marked by impairments in the nervous system. Their onset occurs …
psychiatric conditions marked by impairments in the nervous system. Their onset occurs …
Genes and environments in schizophrenia: the different pieces of a manifold puzzle
JM Réthelyi, J Benkovits, I Bitter - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Genetic research targeting schizophrenia has undergone tremendous development during
recent years. Supported by recently developed high-throughput genotyping technologies …
recent years. Supported by recently developed high-throughput genotyping technologies …
Variation in the major histocompatibility complex [MHC] gene family in schizophrenia: associations and functional implications
Schizophrenia is a chronic debilitating neuropsychiatric disorder with a complex genetic
contribution. Although multiple genetic, immunological and environmental factors are known …
contribution. Although multiple genetic, immunological and environmental factors are known …
Archived neonatal dried blood spot samples can be used for accurate whole genome and exome-targeted next-generation sequencing
Dried blood spot samples (DBSS) have been collected and stored for decades as part of
newborn screening programmes worldwide. Representing almost an entire population …
newborn screening programmes worldwide. Representing almost an entire population …
Evaluation of the relationships of the WBP1L gene with schizophrenia and the general psychopathology scale based on a case–control study
F Guan, T Ni, W Han, H Lin, B Zhang… - American Journal of …, 2020 - Wiley Online Library
WBP1L is a target of microRNA 137 (miR‐137) and has been considered a candidate gene
for schizophrenia (SCZ). To investigate the relationships between WBP1L and SCZ and its …
for schizophrenia (SCZ). To investigate the relationships between WBP1L and SCZ and its …
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and …
Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with
major depressive disorder (MDD). Genetic analyses have reported numerous BD …
major depressive disorder (MDD). Genetic analyses have reported numerous BD …
Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era
G Costain, AS Bassett - The application of clinical genetics, 2012 - Taylor & Francis
Schizophrenia is a complex neuropsychiatric disease with documented clinical and genetic
heterogeneity, and evidence for neurodevelopmental origins. Driven by new genetic …
heterogeneity, and evidence for neurodevelopmental origins. Driven by new genetic …
Cannabinoids and psychotic symptoms: A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene
MP Boks, Y He, CD Schubart, W van Gastel… - Brain, behavior, and …, 2020 - Elsevier
To investigate the biological mechanisms underlying the higher risk for psychosis in those
that use cannabis, we conducted a genome-wide environment-interaction study (GWEIS). In …
that use cannabis, we conducted a genome-wide environment-interaction study (GWEIS). In …
DNA methylome profiling using neonatal dried blood spot samples: a proof-of-principle study
MV Hollegaard, J Grauholm… - Molecular genetics and …, 2013 - Elsevier
DNA methylation is the most common DNA modification and perhaps the best described
epigenetic modification. It is believed to be important for genomic imprinting and gene …
epigenetic modification. It is believed to be important for genomic imprinting and gene …