Comparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats
Background The comparability of gene expression between blood and brain tissues is a
central issue in neuropsychiatric research where the analysis of molecular mechanisms in …
central issue in neuropsychiatric research where the analysis of molecular mechanisms in …
Influence of the NRGN gene on intellectual ability in schizophrenia
K Ohi, R Hashimoto, Y Yasuda, M Fukumoto… - Journal of human …, 2013 - nature.com
Genome-wide association studies have reported an association between schizophrenia and
rs12807809 of the neurogranin (NRGN) gene. We have recently found that an rs12807809 …
rs12807809 of the neurogranin (NRGN) gene. We have recently found that an rs12807809 …
Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia
Transcription factor 4 (TCF4) is a basic helix-loop-helix transcription factor essential for
neurocognitive development. The aberrations in TCF4 are associated with …
neurocognitive development. The aberrations in TCF4 are associated with …
A systematic approach to multifactorial cardiovascular disease: causal analysis
SM Schwartz, HT Schwartz, S Horvath… - … , and vascular biology, 2012 - Am Heart Assoc
The combination of systems biology and large data sets offers new approaches to the study
of cardiovascular diseases. These new approaches are especially important for the common …
of cardiovascular diseases. These new approaches are especially important for the common …
Vaccinia-related kinase 2 controls the stability of the eukaryotic chaperonin TRiC/CCT by inhibiting the deubiquitinating enzyme USP25
Molecular chaperones monitor the proper folding of misfolded proteins and function as the
first line of defense against mutant protein aggregation in neurodegenerative diseases. The …
first line of defense against mutant protein aggregation in neurodegenerative diseases. The …
Vrk2 deficiency elicits aggressive behavior in female zebrafish
R Umeda, H Teranishi, K Hada, N Shimizu… - Genes to …, 2022 - Wiley Online Library
Abstract Vaccinia‐related kinase 2 (VRK2) is a serine/threonine kinase initially identified in
highly proliferative cells such as thymocytes and fetal liver cells, and it is involved in cell …
highly proliferative cells such as thymocytes and fetal liver cells, and it is involved in cell …
Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice
K Braun, BM Häberle, MT Wittmann, DC Lie - BMC neuroscience, 2020 - Springer
Abstract Background Transcription factor 4 (TCF4) has been linked to human
neurodevelopmental disorders such as intellectual disability, Pitt-Hopkins Syndrome …
neurodevelopmental disorders such as intellectual disability, Pitt-Hopkins Syndrome …
Polygenic risk for autism spectrum disorder affects left amygdala activity and negative emotion in schizophrenia
Although the diagnoses based on phenomenology have many practical advantages,
accumulating evidence shows that schizophrenia and autism spectrum disorder (ASD) …
accumulating evidence shows that schizophrenia and autism spectrum disorder (ASD) …
Child Schizophrenia: theory and practice
P Petlovanyi, A Tsarkov - European Journal of Medical and Health …, 2020 - papers.ssrn.com
Child schizophrenia is a mental disorder that affects brain structures, emotional and
cognitive functions. The disorder is characterized by psychotic symptoms: disorder of …
cognitive functions. The disorder is characterized by psychotic symptoms: disorder of …
Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds
Several genes have recently been identified as risk factors for schizophrenia (SZ) by
genome-wide association studies (GWAS), including ZNF804A which is thought to function …
genome-wide association studies (GWAS), including ZNF804A which is thought to function …