Network pharmacology approaches for research of Traditional Chinese Medicines

LI Xiang, LIU Ziqi, L Jie, C Qian, LU Xiaoyan… - Chinese Journal of …, 2023 - Elsevier
Pharmacodynamics material basis and effective mechanisms are the two main issues to
decipher the mechnisms of action of Traditional Chinese medicines (TCMs) for the treatment …

Multi-component Chinese medicine formulas for drug discovery: state of the art and future perspectives

C Zhang, G Chen, G Tang, X Xu, Z Feng, Y Lu… - Acta Materia …, 2023 - scienceopen.com
For hundreds of years, the drug discovery and development industry has aimed at
identifying single components with a clear mechanism of action as desirable candidates for …

Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitro and in vivo experiments

B Ge, R Sang, W Wang, K Yan, Y Yu, L Kong, M Yu… - Phytomedicine, 2023 - Elsevier
Background: Drug-induced liver injury (DILI) is primarily caused by drugs or their
metabolites. Acetaminophen (APAP) is an over-the-counter antipyretic analgesic that …

A review of traditional and current processing methods used to decrease the toxicity of the rhizome of Pinellia ternata in traditional Chinese medicine

W Peng, N Li, E Jiang, C Zhang, Y Huang, L Tan… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance The rhizome of Pinellia ternata (Thunb.) Breit, called
Pinelliae Rhizoma (PR) and Banxia in Chinese, is a well-known traditional Chinese …

Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola …

N Xing, J Qin, D Ren, Q Du, Y Li, J Mi, F Zhang… - Journal of …, 2023 - Elsevier
Ethnopharmacology relevance Rhodiola granules (RG) is a traditional Tibetan medicine
prescription that can be used to improve the symptoms of ischemia and hypoxia in …

Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway

Y You, X Chen, X Chen, H Li, R Zhou, J Zhou… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Jiawei Yanghe Decoction (JWYHD) is a widely
used traditional Chinese medicine prescription in the clinical setting for the treatment of …

Integrated network pharmacology and experimental approach to investigate the protective effect of jin gu lian capsule on rheumatoid arthritis by inhibiting inflammation …

T Chen, S Li, D Lian, Q Hu, H Hou, D Niu… - Drug Design …, 2023 - Taylor & Francis
Purpose This study aimed to investigate the main pharmacological action and underlying
mechanisms of Jin Gu Lian Capsule (JGL) against rheumatoid arthritis (RA) based on …

Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and …

J He, Q Zhang, X Xia, L Yang - Phytomedicine, 2023 - Elsevier
Abstract Background Lagopsis supina (Steph. ex. Willd.) Ikonn.-Gal. is an important
traditional Chinese medicine used to treat various ailments. However, its impact on …

Zingiber officinale Roscoe: A comprehensive review of clinical properties

A Bitari, I Oualdi, R Touzani, M Elachouri… - Materials Today …, 2023 - Elsevier
Zingiber officinale Roscoe, commonly known as ginger, is widely used as a spice or a folk
medicine. Such a plant has been incuriously focused on by publishing extensive papers and …

Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion

F Chen, Y Chai, F Zhang, Y Liu, Y Zhang… - Bioscience …, 2023 - portlandpress.com
Abstract Ethnopharmacological relevance: Salidroside (SAL), a phenolic natural product
present in Rhodiola rosea, are commonly used in the treatment of various ischemic-hypoxic …