Gene therapy holds great promise for treating a multitude of inherited and acquired diseases
by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit …

The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …

Rapidly growing demand of functional polymers in various interdisciplinary areas of
research has accentuated the need for modern synthetic tools to develop advanced …

Zwitterionic polymers, comprising hydrophilic anionic and cationic groups with the same
total number of positive and negative charges on the same monomer residue, have received …

In the past decade, responsive polymers exhibiting reversible or irreversible changes in
physical properties and/or chemical structures in response to external stimuli have been …

Highlights•Minor modifications to polymer structure determine transfection
properties.•Efficient gene delivery requires timely release of DNA.•Serum stability is …

The natural anionic polysaccharide hyaluronic acid (HA) was modified by introducing
reduction-sensitive disulfide bond between the carboxyl groups and the backbone of HA …

Nanomaterials self-assembled from amphiphilic functional copolymers have emerged as
safe and efficient nanocarriers for delivery of therapeutics. Surface engineering of the …

Silicone has been used for peritoneal dialysis (PD) catheters for several decades. However,
bacteria, platelets, proteins, and other biomolecules tend to adhere to its hydrophobic …

Polysulfobetaines, polymers carrying highly polar zwitterionic side chains, present a
promising research field by virtue of their antifouling properties, hemocompatibility, and …