[HTML][HTML] Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
J Han, Y Mu, J Huang - Cell Insight, 2023 - Elsevier
Various post-translational modifications (PTMs) collaboratively fine-tune protein activities.
SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that …
SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that …
Chronic replication stress invokes mitochondria dysfunction via impaired parkin activity
T Kawabata, R Sekiya, S Goto, TS Li - Scientific Reports, 2024 - nature.com
Replication stress is a major contributor to tumorigenesis because it provides a source of
chromosomal rearrangements via recombination events. PARK2, which encodes parkin, a …
chromosomal rearrangements via recombination events. PARK2, which encodes parkin, a …
Inhibition of Atm and Atr kinases affects embryo development and the DNA damage response in sterlet (Acipenser ruthenus)
Embryo development is regulated by numerous interconnected pathways that direct cell fate,
differentiation, and genetic stability. During development, these pathways can be altered by …
differentiation, and genetic stability. During development, these pathways can be altered by …
The exit of naïve pluripotency contains a lipid metabolism-induced checkpoint for genome integrity.
RA de Souza, D Barneda, D Karimlou, NGP Bovee… - bioRxiv, 2024 - biorxiv.org
Pluripotent progenitors undergo dramatic cellular and biochemical transformations during
peri-implantation development. These large-scale reprogramming events are fundamental …
peri-implantation development. These large-scale reprogramming events are fundamental …