Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

The cerebrovascular-specific molecular mechanism in Alzheimer's disease (AD) was
investigated by employing comprehensive and accurate quantitative proteomics. Highly …

Alzheimer's disease (AD) progressively inflicts impairment of synaptic functions with notable
deposition of amyloid-β (Aβ) as senile plaques within the extracellular space of the brain …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with continual decline
in cognition and ability to perform routine functions such as remembering familiar places or …

The Notch signaling pathway is an evolutionarily conserved cell signaling system known to
be involved in vascular development and function. Recent evidence suggests that …

Alzheimer's disease (AD) is the most common form of age-related dementias. In addition to
genetics, environment, and lifestyle, growing evidence supports vascular contributions to …

Neurotrophic factors (NTFs) are involved in the pathophysiology of neurological disorders
such as dementia, stroke and traumatic brain injury (TBI), and constitute molecular targets of …

Abstract Purpose of Review This comprehensive review delves into the intricate interplay
between Alzheimer's disease (AD) and osteoporosis, two prevalent conditions with …

Neurovascular coupling is a critical brain mechanism whereby changes to blood flow
accompany localised neural activity. The breakdown of neurovascular coupling is linked to …