Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …

Two recent studies raised new concerns regarding cardiovascular (CV) risks with
testosterone (T) therapy. This article reviews those studies as well as the extensive literature …

Introduction The relationship between endogenous testosterone (T) levels and
cardiovascular (CV) risk in men is conflicting. Aim To verify whether endogenous T levels …

Abstract Hypogonadism or Testosterone Deficiency (TD) in adult men as defined by low
levels of serum testosterone accompanied by characteristic symptoms and/or signs as …

Female androgen excess and male androgen deficiency manifest with an overlapping
adverse metabolic phenotype, including abdominal obesity, insulin resistance, type 2 …

Context: Late-onset hypogonadism (LOH) has recently been defined as a syndrome in
middle-aged and elderly men reporting sexual symptoms in the presence of low T. The …

Context: Testosterone (T) levels decline with age and lower T has been associated with
increased mortality in aging men. However, the associations of its metabolites …

Context: During aging, total testosterone (TT) declines and SHBG increases, resulting in a
greater decrease in calculated free T (cFT). Currently, guidelines suggest using TT to …

Androgens are potent drugs requiring prescription for valid medical indications but are
misused for invalid, unproven, or off-label reasons as well as being abused without …

Several large cohort studies have disclosed the trajectories of sex steroids changes
overtime in men and their clinical significance. In men the slow, physiological decline of …