Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (Covid‐19)

Y Zhou, J Chi, W Lv, Y Wang - Diabetes/metabolism research …, 2021 - Wiley Online Library
The outbreak of the coronavirus disease 2019 (Covid‐19) has become an evolving
worldwide health crisis. With the rising prevalence of obesity and diabetes has come an …

[HTML][HTML] The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens

L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …

Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution

W Ma, H Fu, F Jian, Y Cao, M Li - Nature Ecology & Evolution, 2023 - nature.com
Mutations in the SARS-CoV-2 genome could confer resistance to pre-existing antibodies
and/or increased transmissibility. The recently emerged Omicron subvariants exhibit a …

[HTML][HTML] The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity

Q Li, J Wu, J Nie, L Zhang, H Hao, S Liu, C Zhao… - Cell, 2020 - cell.com
The spike protein of SARS-CoV-2 has been undergoing mutations and is highly
glycosylated. It is critically important to investigate the biological significance of these …

[HTML][HTML] Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis

Y Zhou, Q Yang, J Chi, B Dong, W Lv, L Shen… - International Journal of …, 2020 - Elsevier
Objectives Existing findings regarding the relationship between comorbidities and the
severity of coronavirus disease 2019 (COVID-19) are inconsistent and insufficient. The aim …

[HTML][HTML] SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines

S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …

Genetic diversity and evolution of SARS-CoV-2

T Phan - Infection, genetics and evolution, 2020 - Elsevier
COVID-19 is a viral respiratory illness caused by a new coronavirus called SARS-CoV-2.
The World Health Organization declared the SARS-CoV-2 outbreak a global public health …

[HTML][HTML] Impact of obesity on influenza A virus pathogenesis, immune response, and evolution

R Honce, S Schultz-Cherry - Frontiers in immunology, 2019 - frontiersin.org
With the rising prevalence of obesity has come an increasing awareness of its impact on
communicable disease. As a consequence of the 2009 H1N1 influenza A virus pandemic …

[HTML][HTML] Viral quasispecies

E Domingo, C Perales - PLoS genetics, 2019 - journals.plos.org
Viral quasispecies refers to a population structure that consists of extremely large numbers
of variant genomes, termed mutant spectra, mutant swarms or mutant clouds. Fueled by high …

[HTML][HTML] Multiple assays in a real-time RT-PCR SARS-CoV-2 panel can mitigate the risk of loss of sensitivity by new genomic variants during the COVID-19 outbreak

L Peñarrubia, M Ruiz, R Porco, SN Rao… - International Journal of …, 2020 - Elsevier
Objectives In this study, five SARS-CoV-2 PCR assay panels were evaluated against the
accumulated genetic variability of the virus to assess the effect on sensitivity of the individual …