Emerging concepts and technologies in vaccine development
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …
by pathogens, there are still known diseases and emerging pathogens for which the …
Adjuvant system AS01: helping to overcome the challenges of modern vaccines
AM Didierlaurent, B Laupèze, A Di Pasquale… - Expert review of …, 2017 - Taylor & Francis
Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …
[HTML][HTML] Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled …
Background Stalled progress in controlling Plasmodium falciparum malaria highlights the
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …
A monoclonal antibody for malaria prevention
MR Gaudinski, NM Berkowitz, AH Idris… - … England Journal of …, 2021 - Mass Medical Soc
Background Additional interventions are needed to reduce the morbidity and mortality
caused by malaria. Methods We conducted a two-part, phase 1 clinical trial to assess the …
caused by malaria. Methods We conducted a two-part, phase 1 clinical trial to assess the …
Coral reef ecosystem services in the Anthropocene
Coral reefs underpin a range of ecosystem goods and services that contribute to the well‐
being of millions of people. However, tropical coral reefs in the Anthropocene are likely to be …
being of millions of people. However, tropical coral reefs in the Anthropocene are likely to be …
Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis
Background Trend data for causes of child death are crucial to inform priorities for improving
child survival by and beyond 2015. We report child mortality by cause estimates in 2000–13 …
child survival by and beyond 2015. We report child mortality by cause estimates in 2000–13 …
Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised …
S Rts - Lancet, 2015 - thelancet.com
Background The efficacy and safety of the RTS, S/AS01 candidate malaria vaccine during
18 months of follow-up have been published previously. Herein, we report the final results …
18 months of follow-up have been published previously. Herein, we report the final results …
The contribution of vaccination to global health: past, present and future
B Greenwood - … Transactions of the Royal Society B …, 2014 - royalsocietypublishing.org
Vaccination has made an enormous contribution to global health. Two major infections,
smallpox and rinderpest, have been eradicated. Global coverage of vaccination against …
smallpox and rinderpest, have been eradicated. Global coverage of vaccination against …
[HTML][HTML] Key roles of adjuvants in modern vaccines
SG Reed, MT Orr, CB Fox - Nature medicine, 2013 - nature.com
Vaccines containing novel adjuvant formulations are increasingly reaching advanced
development and licensing stages, providing new tools to fill previously unmet clinical …
development and licensing stages, providing new tools to fill previously unmet clinical …