Current strategies of antiviral drug discovery for COVID-19

M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

Novel CYP11A1-derived vitamin D and lumisterol biometabolites for the management of COVID-19

S Qayyum, RM Slominski, C Raman, AT Slominski - Nutrients, 2022 - mdpi.com
Vitamin D deficiency is associated with a higher risk of SARS-CoV-2 infection and poor
outcomes of the COVID-19 disease. However, a satisfactory mechanism explaining the …

Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase

F Munafò, E Donati, N Brindani, G Ottonello… - Scientific Reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a
global health pandemic. Among the viral proteins, RNA-dependent RNA polymerase (RdRp) …

In silico drug repurposing carvedilol and its metabolites against SARS-CoV-2 infection using molecular docking and molecular dynamic simulation approaches

C Zhang, J Liu, Y Sui, S Liu, M Yang - Scientific Reports, 2023 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by the infection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a significant impact on …

Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the In-Silico World

MF Rehman, S Akhter, AI Batool, Z Selamoglu… - Antibiotics, 2021 - mdpi.com
The SARS CoV-2 pandemic has affected millions of people around the globe. Despite many
efforts to find some effective medicines against SARS CoV-2, no established therapeutics …

Progression of antiviral agents targeting viral polymerases

S Peng, H Wang, Z Wang, Q Wang - Molecules, 2022 - mdpi.com
Viral DNA and RNA polymerases are two kinds of very important enzymes that synthesize
the genetic materials of the virus itself, and they have become extremely favorable targets for …

Network for network concept offers new insights into host-SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs

N Eskandarzade, A Ghorbani, S Samarfard… - Computers in biology …, 2022 - Elsevier
Abstract SARS-CoV-2, the causal agent of COVID-19, is primarily a pulmonary virus that can
directly or indirectly infect several organs. Despite many studies carried out during the …

Exploration of potent antiviral phytomedicines from Lauraceae family plants against SARS-CoV-2 RNA-dependent RNA polymerase

AA Rabaan, MA Halwani, M Aljeldah… - Journal of …, 2023 - Taylor & Francis
RNA-dependent RNA polymerase, also known as RdRp, is a possible therapeutic target that
could be used to suppress the proliferation of RNA viruses such as SARS-CoV-2. This …

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic

BA Comunale, RJ Larson, E Jackson-Ward, A Singh… - Viruses, 2023 - mdpi.com
Background: As long as COVID-19 endures, viral surface proteins will keep changing and
new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective …

[HTML][HTML] Bats-associated beta-coronavirus detection and characterization: First report from Pakistan

S Rahman, S Ullah, ZK Shinwari, M Ali - Infection, Genetics and Evolution, 2023 - Elsevier
Bats remains as reservoirs for highly contagious and pathogenic viral families including the
Coronaviridae, Filoviridae, Paramyxoviruses, and Rhabdoviridae. Spill over of viral species …