MicroRNAs (miRNAs) are defined as small non-coding RNAs~ 22 nt in length. They regulate
gene expression at a post-transcriptional level through complementary base pairing with the …

We present FATHMM-XF, a method for predicting pathogenic point mutations in the human
genome. Drawing on an extensive feature set, FATHMM-XF outperforms competitors on …

Darwin's finches, inhabiting the Galápagos archipelago and Cocos Island, constitute an
iconic model for studies of speciation and adaptive evolution. Here we report the results of …

It is estimated that 350 million individuals worldwide suffer from rare diseases, which are
predominantly caused by mutation in a single gene. The current molecular diagnostic rate is …

To connect human biology to fish biomedical models, we sequenced the genome of spotted
gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome …

Over 100 years of studies in Drosophila melanogaster and related species in the genus
Drosophila have facilitated key discoveries in genetics, genomics, and evolution. While high …

INTRODUCTION The DNA of protein-coding genes is transcribed into mRNA, which is
translated into proteins. The “coding genome” describes the DNA that contains the …

Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great
Lakes of East Africa. To understand the molecular mechanisms underlying cichlid …

The success of personalized genomic medicine depends on our ability to assess the
pathogenicity of rare human variants, including the important class of missense variation …

Estrogen receptor α (ERα) is a hormone receptor and key driver for over 70% of breast
cancers that has been studied for decades as a transcription factor. Unexpectedly, we …