[HTML][HTML] Bioactive natural products in COVID-19 therapy

Z Wang, N Wang, L Yang, X Song - Frontiers in Pharmacology, 2022 - frontiersin.org
The devastating COVID-19 pandemic has caused more than six million deaths worldwide
during the last 2 years. Effective therapeutic agents are greatly needed, yet promising magic …

[HTML][HTML] Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

L Liu, J Du, S Yang, B Zheng, J Shen, J Huang, L Cao… - Redox Biology, 2023 - Elsevier
Viral infection-induced cell death has long been considered as a double-edged sword in the
inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 …

[HTML][HTML] Glucosinolates, a natural chemical arsenal: More to tell than the myrosinase story

RM Abdel-Massih, E Debs, L Othman, J Attieh… - Frontiers in …, 2023 - frontiersin.org
Glucosinolates are a group of thioglucosides that belong to the class of plant nitrogen-
containing natural products. So far, very little biological activity has been associated with …

[HTML][HTML] Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

CA Labarrere, GS Kassab - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus
disease 19 (COVID-19) has numerous risk factors leading to severe disease with high …

[HTML][HTML] Food plant secondary metabolites antiviral activity and their possible roles in SARS-CoV-2 treatment: an overview

D Giordano, A Facchiano, V Carbone - Molecules, 2023 - mdpi.com
Natural products and plant extracts exhibit many biological activities, including that related to
the defense mechanisms against parasites. Many studies have investigated the biological …

Effects of Sulforaphane on SARS‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 'cytokine storm'

J Gasparello, G Marzaro, C Papi… - International …, 2023 - spandidos-publications.com
Since its spread at the beginning of 2020, the coronavirus disease 2019 (COVID‑19)
pandemic represents one of the major health problems. Despite the approval, testing, and …

[HTML][HTML] A sustainable photochemical aerobic sulfide oxidation: access to sulforaphane and modafinil

E Skolia, PL Gkizis, CG Kokotos - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
Sulfoxide-containing molecules are an important class of compounds in the pharmaceutical
industry and many efforts have been made to develop new and green protocols, targeting …

[HTML][HTML] Enhancement of ultrasound-assisted extraction of sulforaphane from broccoli seeds via the application of microwave pretreatment

Y Liu, D Zhang, X Li, J Xiao, L Guo - Ultrasonics Sonochemistry, 2022 - Elsevier
In this study, microwave pretreatment and grinding treatment were used to enhance
sulforaphane formation, then ultrasonic-assisted extraction (UAE) was applied to extract …

Sulforaphane delays intervertebral disc degeneration by alleviating endoplasmic reticulum stress in nucleus pulposus cells via activating Nrf‐2/HO‐1

X Lu, G Xu, Z Lin, J Song, Y Zhang… - Oxidative medicine …, 2023 - Wiley Online Library
Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain, which
brings heavy burdens to individuals and society. The mechanism of IVDD is complex and …