Efficacy of repurposed antiviral drugs: lessons from COVID-19

MA Martinez - Drug Discovery Today, 2022 - Elsevier
The clinical, social, and economic impacts of the coronavirus disease 2019 (COVID-19)
pandemic, originated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies

ES Vaz, SV Vassiliades, J Giarolla, MC Polli… - European Journal of …, 2023 - Springer
Introduction Drug repositioning is a strategy to identify a new therapeutic indication for
molecules that have been approved for other conditions, aiming to speed up the traditional …

Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper

T Marjot, CS Eberhardt, T Boettler, LS Belli… - Journal of …, 2022 - Elsevier
The COVID-19 pandemic has presented a serious challenge to the hepatology community,
particularly healthcare professionals and patients. While the rapid development of safe and …

SARS-CoV-2-induced myocarditis: a state-of-the-art review

F Nappi, SS Avtaar Singh - Viruses, 2023 - mdpi.com
In this review, we investigated whether severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can directly cause myocarditis with severe myocardial damage induced by …

Perspectives on subcutaneous infliximab for rheumatic diseases and inflammatory bowel disease: before, during, and after the COVID-19 era

S Schreiber, S Ben-Horin, R Alten, R Westhovens… - Advances in …, 2022 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic has prompted significant
changes in patient care in rheumatology and gastroenterology, with clinical guidance issued …

New applications of JAK/STAT inhibitors in pediatrics: current use of ruxolitinib

A Marcuzzi, E Rimondi, E Melloni, A Gonelli… - Pharmaceuticals, 2022 - mdpi.com
Janus kinases (JAK) are a family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) that
transduce cytokine-mediated signals through the JAK–STAT metabolic pathway. These …

A review of potential therapeutic strategies for COVID-19

J Meng, R Li, Z Zhang, J Wang, Q Huang, D Nie, K Fan… - Viruses, 2022 - mdpi.com
Coronavirus disease 2019 is a rather heterogeneous disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat …

Molecular insights of SARS-CoV-2 antivirals administration: A balance between safety profiles and impact on cardiovascular phenotypes

F Nappi, A Iervolino, SS Avtaar Singh - Biomedicines, 2022 - mdpi.com
The COVID-19 pandemic has resulted in a complex clinical challenge, caused by a novel
coronavirus, partially similar to previously known coronaviruses but with a different pattern of …

S1-Leitlinie zur Versorgung von Lebertransplantierten während der COVID-19-Pandemie–AWMF-Registernummer: 021-031–Stand 15. Juni 2022

F Tacke, M Cornberg, M Sterneck… - Zeitschrift für …, 2022 - thieme-connect.com
Die Lebertransplantation ist eine lebensrettende Option für Patienten mit Leberzirrhose,
hepatozellulärem Karzinom, genetischen, metabolischen oder cholestatischen …

Janus kinases inhibitors for coronavirus disease-2019: A pairwise and Bayesian network meta-analysis

J Niu, Z Lin, Z He, X Yang, L Qin, S Feng, L Guan… - Frontiers in …, 2022 - frontiersin.org
Background JAK (Janus kinases) inhibitors have been proposed as a promising treatment
option for the coronavirus disease-2019 (COVID-19). However, the benefits of JAK inhibitors …