Methods to study adult hippocampal neurogenesis in humans and across the phylogeny
J Terreros‐Roncal, M Flor‐García… - …, 2023 - Wiley Online Library
The hippocampus hosts the continuous addition of new neurons throughout life—a
phenomenon named adult hippocampal neurogenesis (AHN). Here we revisit the …
phenomenon named adult hippocampal neurogenesis (AHN). Here we revisit the …
Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human
tissue is important for understanding disease pathologies. However, several experimental …
tissue is important for understanding disease pathologies. However, several experimental …
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
Multimodal astrocyte–neuron communications govern brain circuitry assembly and function.
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …
Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?
The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …
or neurological diseases represents a particularly attractive alternative to conventional …
Neuronal ambient RNA contamination causes misinterpreted and masked cell types in brain single-nuclei datasets
E Caglayan, Y Liu, G Konopka - Neuron, 2022 - cell.com
Ambient RNA contamination in single-cell and single-nuclei RNA sequencing (snRNA-seq)
is a significant problem, but its consequences are poorly understood. Here, we show that …
is a significant problem, but its consequences are poorly understood. Here, we show that …
Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models
P Mews, AM Cunningham, J Scarpa… - Science …, 2023 - science.org
Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates
represent a substantial public health crisis that exacts tremendous personal and financial …
represent a substantial public health crisis that exacts tremendous personal and financial …
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition
The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
[HTML][HTML] Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use …
Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …
accompanied by a surge of overdose deaths. While opioid dependence has been …
[HTML][HTML] Automatic cell-type harmonization and integration across Human Cell Atlas datasets
Harmonizing cell types across the single-cell community and assembling them into a
common framework is central to building a standardized Human Cell Atlas. Here, we present …
common framework is central to building a standardized Human Cell Atlas. Here, we present …