Nucleic acid molecules possess many superior properties, including high designability and
structural predictability, making them attractive biosensing and bioimaging tools. The …

Recent years have seen continued expansion of the functionality of lab on a chip (LOC)
devices. Indeed LOCs now provide scientists and developers with useful and versatile …

Applying rational design, we developed 17 kDa cyanobacteriochrome-based near-infrared
(NIR-I) fluorescent protein, miRFP718nano. miRFP718nano efficiently binds endogenous …

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in
treating both hematologic malignancies and solid tumors. Although instances of rapid tumor …

For generations researchers have been observing the dynamic processes of life through the
lens of a microscope. This has offered tremendous insights into biological phenomena that …

Since the discovery of fluorescent proteins (FPs), their rich fluorescence spectra and
photochemical properties have promoted widespread biological research applications. FPs …

Due to their exceptional solubility and stability, nanobodies have emerged as powerful
building blocks for research tools and therapeutics. However, their generation in llamas is …

Despite drastic cellular changes during cleavage, a mitotic spindle assembles in each
blastomere to accurately segregate duplicated chromosomes. Mechanisms of mitotic spindle …

A grand challenge in biosensor design is to develop a single-molecule, fluorescent protein-
based platform that can be easily adapted to recognize targets of choice. Here, we created a …

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), an infectious disease that has become a serious burden on …