Fibrotic disease, which is implicated in almost half of all deaths worldwide, is the result of an
uncontrolled wound healing response to injury in which tissue is replaced by deposition of …

The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

Background: Ancestry is often viewed as a more objective and less objectionable population
descriptor than race or ethnicity. Perhaps reflecting this, usage of the term “ancestry” is …

Simple Summary Clear cell renal cell carcinoma is a type of kidney cancer which comprises
the majority of all renal cell carcinomas. Many efforts have been made to identify biomarkers …

About 37 million people in the United States have chronic kidney disease, a disease that
encompasses multiple causes. About 10% or more of kidney diseases in adults and as …

Research to understand human genomic variation and its implications in health has great
potential to contribute in the reduction of health disparities. Biological anthropology can play …

Heparan sulfate (HS) is an important component of the kidney anionic filtration barrier, the
glomerular basement membrane (GBM). HS chains attached to proteoglycan protein cores …

The four key methods to stratify chronic kidney disease risk are genomics, multiomics,
supervised and unsupervised machine learning methods. Polygenic risk scores utilize …

Longitudinal studies provide unique insights into the impact of environmental factors and
lifespan issues on health and disease. Here we investigate changes in body composition in …

Chronic kidney disease (CKD) is a complex disorder that causes a gradual loss of kidney
function, affecting approximately 9.1% of the world's population. Here, we use a soft …