5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a
substance isolated from blood. The neural effects of 5-HT have been well investigated and …

Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery …

Context: A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been
reported. This is the first study that uses liquid chromatography–tandem mass spectrometry …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Metabotropic glutamate (mGlu) receptors are G-protein-coupled receptors expressed
primarily on neurons and glial cells, where they are located in the proximity of the synaptic …

Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

Context: Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of
somatic KCNJ5 mutations suggests a genetic explanation. Objectives: The objectives of this …

Primary aldosteronism (PA) secondary to excessive and/or autonomous aldosterone
secretion from the renin–angiotensin system accounts for∼ 10% of cases of hypertension …