Background Proteomic profiling may allow identification of plasma proteins that associate
with subsequent changesin kidney function, elucidating biologic processes underlying the …

Background and Aims. The nucleotide‐binding domain and leucine‐rich repeat containing
PYD‐3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney …

Chronic kidney disease (CKD) is a lethal and rapidly increasing burden on society. Despite
this, there are relatively few therapies in development for the treatment of CKD. Several …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Renal phosphate handling critically determines plasma phosphate and whole body
phosphate levels. Filtered phosphate is mostly reabsorbed by Na+-dependent phosphate …

Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an
independent predictor of disease progression. Deposition of pathological matrix in the walls …

Genome-wide association studies (GWAS) have identified> 100 loci of chronic kidney
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …

Chronic kidney disease (CKD) has diverse phenotypic manifestations including structural
(such as fibrosis) and functional (such as glomerular filtration rate and albuminuria) …

Uromodulin (also known as Tamm–Horsfall protein) is a kidney-specific glycoprotein
secreted bidirectionally into urine and into the circulation, and it is the most abundant protein …

Long noncoding RNAs (lncRNAs) are emerging as key species-specific regulators of
cellular and disease processes. To identify potential lncRNAs relevant to acute and chronic …